t-PA是近几年引入眼科的一种新型纤溶酶原激活剂,它对眼内的出血和渗出疾患有高效特异的治疗作用,且疗效优于旧的纤溶药物。本文对t-PA纤溶作用的机理、在眼科的应用、眼部给药途径、在眼内的药动学、眼用t-PA的配制和保存及眼部应用的副作用和预防进行了综述。t-PA在眼科的应用尚待进一步开发研究。 t-PA is a new type of plasminogen activator that has been introduced into ophthalmology in recent years. It has a highly specific and specific therapeutic effect on bleeding and exudative conditions in the eye and is superior to the old fibrinolytic drugs. This review summarizes the mechanism of t-PA fibrinolysis, its application in ophthalmology, routes of ocular administration, pharmacokinetics in the eye, preparation and preservation of ocular t-PA, and eye side effects and prophylaxis . The application of t-PA in ophthalmology remains to be further developed.