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至今,运动神经元疾病(MND)伴淋巴瘤共报道34例.本文作者又研究了9例某中心医院(CPMC)该病患者.MND临床综合征分五大类:进行性脊髓肌萎缩(PSMA)、肌萎缩侧索硬化(ALS)、ALS伴可能性上运动神经元(UMN)症状(ALS-PUMNS)、运动神经病和多灶性传导阻滞(MCB).研究结果:1.肿瘤病理:9例CPMC患者中有4名是何杰金氏病(HD),5例是非何杰金氏淋巴瘤(NHL),其中2例有淋巴细胞性淋巴瘤,3例有慢性淋巴瘤细胞白血病(CLL).2.临床综合征:淋巴瘤的组织学类型和MND临床综合征无明显联系.一例尸检发现何杰金氏淋巴瘤(HL)在21个月前就有
To date, 34 cases of MND accompanied by lymphoma have been reported.In this study, 9 cases of this disease were studied in a central hospital (CPMC) .The clinical manifestations of MND were divided into five categories: progressive spinal muscular atrophy (PSMA) , ALS, ALS-PUMNS, motor neuropathy and multifocal conduction block (MCB) in ALS patients.Results: 1. Four of the patients with CPMC were Hodgkin’s disease (HD) and five were non-Hodgkin’s lymphoma (NHL), two of whom had lymphocytic lymphoma and three had chronic lymphocytic leukemia (CLL ) .2 Clinical syndromes: The histological type of lymphoma is not significantly associated with the MND clinical syndrome. One autopsy revealed Hodgkin’s lymphoma (HL) 21 months prior