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本研究通过组织细胞培养实验及动物实验研究对士的宁及复方士的宁点眼液进行了抗Ⅰ型单纯疱疹病毒（Ｈｅｒｐｅｓｓｉｍｐｌｅｘｖｉｒｕｓｔｙｐｅ１，ＨＳＶ－Ⅰ）的研究。结果表明：１．士的宁的细胞毒性低，细胞培养７２小时观察，细胞最大耐受浓度为１０００ｕｇ／ｍｌ；２．利用细胞培养技术，经四种不同给药途径研究证实，士的宁及复方士的宁不仅对ＨＳＶ－Ⅰ有直接抑制作用，而且对病毒吸附、侵入细胞有较好的防治作用，四种药物抗ＨＳＶ－Ⅰ的作用强度依次为复方士的宁＞士的宁≈无环鸟苷＞吗啉胍；３．在治疗兔实验性单纯疱疹性角膜炎（Ｈｅｒｐｅｓｓｉｍｐｌｅｘｖｉｒｕｓｋｅｒａｔｉｔｉｓ，ＨＳＫ）实验中发现复方士的宁及士的宁点眼液均有良好的治疗ＨＳＫ的作用，尤以前者疗效显著，平均治愈日为６．８３日，无毒副作用及过敏反应发生。
In this study, Herpes Simplexvirustype 1 (HSV-Ⅰ) was studied in strychnine and fufangshi ningjingye by tissue culture experiments and animal experiments. The result shows: 1. Strychnine cytotoxic low, cell culture 72 hours observed, the cell maximum tolerated concentration of 1000ug / ml; 2. The use of cell culture technology, the study of four different routes of administration confirmed that strychnine and strychnine not only HSV-Ⅰ have a direct inhibitory effect, but also for the virus adsorption, invasion of cells have a better preventive effect of the four drugs Intensity of anti-HSV-Ⅰ followed by Fufangshizhi Ning> strychnine ≈ acyclovir> Moroxydine; 3. Herpes simplex keratitis (Herkssxmplexviruskeratitis, HSK) experiments found that the compound strychnine and strychnine eye drops have a good effect on the treatment of HSK, especially in the former significant effect, the average cure day was 6.83 Day, non-toxic side effects and allergic reactions.