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作者比较了硫糖铝悬液每天2次与安慰剂治疗267例急性球溃疡(直径5～25mm)的疗效,硫糖铝组于第4及8周时有较高的溃疡愈合率。本文是一项8周、双盲、随机、安慰剂对照、平行组的多中心研究,患者用10ml 硫糖铝悬液(1g/5ml)或安慰剂悬液,每日2次。于试验前,治疗后2、4、8周时复查内镜,愈合定义为溃疡有完全性上皮再生。治疗与对照组在患者数、年龄、性别、吸烟情况,开始时溃疡大小、溃疡史及白天与夜间的疼痛症状积分等方面有可比性。130例硫糖铝组患者2周时愈合者21例(16%),而137例安慰剂组为16例(12%),二组间无统计学差异;4周时分别为66例(51%)及37例
The authors compared the efficacy of sucralfate twice daily with placebo in the treatment of 267 cases of acute ball ulcers (5-25 mm in diameter), with a higher ulcer healing rate at weeks 4 and 8 in the sucralfate group. This is an 8-week, double-blind, randomized, placebo-controlled, parallel-group multicenter study in patients with 10 ml sucralfate suspension (1 g / 5 ml) or placebo suspension twice daily. Endoscopy was performed at 2, 4, and 8 weeks after treatment, and healing was defined as complete epithelial regeneration of the ulcer. Treatment and control groups were comparable in terms of number of patients, age, sex, smoking, ulcer size at the beginning, history of ulcers, and pain symptom scores during the day and night. Of the 130 sucralfate-treated patients, 21 (16%) healed at 2 weeks and 137 (12%) received placebo, with no significant difference between the two groups; 66 (51 %) And 37 cases