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目的 :探讨慢性HBV感染相关肝细胞癌血清中高尔基体蛋白73(GP73)和甲胎蛋白异质体(AFP-L3)水平的变化及其在疾病诊断中的价值意义。方法 :应用酶联免疫吸附测定法(ELISA)检测167例慢性HBV感染相关肝癌,92例肝硬化患者和134例慢性肝炎血清GP73和AFP-L3水平的变化,并分析其余ALP、GGT、ALT、AST和AFP的相关性。结果 :慢性HBV感染相关肝细胞癌患者血清GP73和AFP-L3水平明显高于肝硬化和慢性肝炎,与ALP、GGT和AFP均存在明显相关性。结论 :血清肿瘤标志物均具有广谱性,诊断HCC时缺乏高度的特异性,进行单项检测时,易弃漏部分阳性患者,阳性率不高。联合检测GP73和AFP-L3可联合检测提高诊断率,为早期发现及治疗提供依据。
Objective: To investigate the changes of serum levels of GP73 and AFP-L3 in hepatocellular carcinoma associated with chronic HBV infection and their significance in the diagnosis of the disease. Methods: Serum levels of GP73 and AFP-L3 in 167 patients with chronic HBV infection, 92 patients with liver cirrhosis and 134 patients with chronic hepatitis were detected by enzyme linked immunosorbent assay (ELISA). The levels of ALP, GGT, ALT, Correlation of AST and AFP. Results: Serum GP73 and AFP-L3 levels in patients with chronic HBV infection-related hepatocellular carcinoma were significantly higher than those in patients with cirrhosis and chronic hepatitis, showing significant correlation with ALP, GGT and AFP. Conclusion: The serum tumor markers have a broad spectrum of diagnosis, the lack of a high degree of specificity in the diagnosis of HCC, single test, easy to give up part of the positive patients, the positive rate is not high. Joint detection of GP73 and AFP-L3 can be combined to improve the diagnostic rate, providing the basis for early detection and treatment.