【摘 要】
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Fiber photometry is a recently-developed method that indirectly measures neural activity by moni-toring Ca2+signals in genetically-identified neuronal populations.Although fiber photometry is widely used in neuroscience research,the relationship between t
【机 构】
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Jiangsu Key Laboratory of Brain Disease and Bioinforma-tion,Research Center for Biochemistry and Mol
论文部分内容阅读
Fiber photometry is a recently-developed method that indirectly measures neural activity by moni-toring Ca2+signals in genetically-identified neuronal populations.Although fiber photometry is widely used in neuroscience research,the relationship between the recorded Ca2+signals and direct electrophysiological measurements of neural activity remains elusive.Here,we simultaneously recorded odor-evoked Ca2+and elec-trophysiological signals[single-unit spikes and local field potentials(LFPs)]from mitral/tufted cells in the olfactory bulb of awake,head-fixed mice.Odors evoked responses in all types of signal but the response characteristics(e.g.,type of response and time course)differed.The Ca2+signal was correlated most closely with power in the 3-band of the LFP.The Ca2+signal performed slightly better at odor classification than high-γ oscillations,worse than single-unit spikes,and similarly to β oscillations.These results provide new information to help researchers select an appropriate method for monitoring neural activity under specific conditions.
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