【摘 要】
：
The myelin regulatory factor gene (MYRF) encodes a protein evolutionarily conserved from invertebrates to vertebrates,representing a novel type of membrane-bound transcriptional factor (MBTF).In vertebrates,MYRF protein is required for myelin development
【机 构】
：
Institute of Life Sciences,Zhejiang Key Laboratory of Organ Development and Regeneration,College of
论文部分内容阅读
The myelin regulatory factor gene (MYRF) encodes a protein evolutionarily conserved from invertebrates to vertebrates,representing a novel type of membrane-bound transcriptional factor (MBTF).In vertebrates,MYRF protein is required for myelin development and mainte-nance [1,2].Unlike other oligodendrocyte-specific tran-scription factors,it is initially synthesized as a conserved type-II membrane protein,containing a N-terminal proline-rich (Pro) domain,a putative yeast Ndt80-1ike DNA binding domain (DBD),two nuclear localization signal motifs,an intramolecular chaperone auto-processing (ICA)domain,a transmembrane domain,and a function-unknown C-terminal conserved (C) domain (Fig 1).Among these conserved domains,the DBD directly binds to the pro-moters of target genes,the transmembrane domain anchors MYRF to the endoplasmic reticulum (ER) membrane,and the ICA domain drives the homo-trimerization of MYRF protein and subsequently induces its self-cleavage via its intrinsic peptidase activity [3,4].
其他文献
Major depressive disorder (MDD),also referred to as depression,is one of the most common psychiatric disorders with a high economic burden.The etiology of depression is still not clear,but it is generally believed that MDD is a multifactorial disease caus
Neurodegeneration,a defining hallmark of Alzheimer\'s disease (AD),features the progressive loss of neuronal structure and functions.Therapeutic approaches to AD show limited efficiency in halting the neurodegeneration to date.Given the lack of neuronal
Dear Editor,rnAcute disseminated encephalomyelitis (ADEM) is an immune-mediated demyelinating disorder characterized by a widespread attack of inflammation in the brain and spinal cord that damages myelin[1].ADEM is life-threatening and among the most fre
Inflammation typically induces pain by producing pro-inflammatory mediators,but increasing evidence also indicates a role for inflammation in the resolution of pain by inducing anti-inflammatory and pro-resolution media-tors[1,2].A recent Nature paper fro
Alzheimer\'s disease (AD),the most common type of dementia,is a devastating neurodegenerative disorder that seriously afflicts millions of patients and their families due to the lack of effective therapeutic drugs and methods.rnElucidating the pathogene
Whether in the West or the East,the connection between the ear and the rest of the body has been explored for a long time.Especially in the past century or more,the relevant theoretical and applied research on the ear has greatly promoted the development
Learning to associate a positive or negative experience with an unrelated cue after the presentation of a reward or a punishment defines associative learning.The ability to form associative memories has been reported in animal species as complex as humans
Grey matter (GM) alterations may contribute to cognitive decline in individuals with white matter hyper-intensities (WMH) but no consensus has yet emerged.Here,we investigated cortical thickness and grey matter volume in 23 WMH patients with mild cognitiv
Parkinson\'s disease(PD)is the second most common neurodegenerative disease,which manifests with both motor and non-motor symptoms.Circadian rhythm dysregulation,as one of the most challenging non-motor features of PD,usually appears long before obvious
Extracellular deposition of amyloid-β (Aβ) is one of the pathological hallmarks of Alzheimer\'s disease (AD) [1].It has emerged that innate immune activation plays an important role in AD and other neurodegenerative diseases[2].On the understanding of t