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目的探讨窒息新生儿血清促生长激素释放多肽(Ghrelin)及超敏C反应蛋白(hs-CRP)水平的动态变化。方法选择我院产科2010年4月至2011年6月分娩的轻度、重度窒息新生儿各40例为观察组,检测脐血、急性期(1～3天)及恢复期(7～10天)血清Ghrelin和hs-CRP水平;选择同期住院无窒息史的健康新生儿40例为对照组,检测脐血Ghrelin和hs-CRP水平。结果窒息组Ghrelin水平随病程变化先降后升,急性期[(22.1±8.8)ng/ml]与恢复期[(33.2±12.2)ng/ml]均低于脐血[(38.0±13.2)ng/ml],恢复期高于急性期,差异有统计学意义(P<0.05)。对照组脐血Ghrelin水平[(72.3±15.6)mg/ml]明显高于窒息组,轻度窒息组脐血、急性期、恢复期Ghrelin水平高于重度窒息组。窒息组hs-CRP水平随病程变化先升后降,急性期[(0.48±0.22)mg/L]高于脐血[(0.14±0.11)mg/L],恢复期[(0.12±0.09)mg/L]低于急性期,差异有统计学意义(P<0.05)。对照组脐血hs-CRP水平[(0.02±0.00)mg/L]低于窒息组;轻度窒息组急性期低于重度窒息组,脐血和恢复期与重度窒息组比较差异无统计学意义。结论 Ghrelin、hs-CRP水平与窒息的发生、发展有关,窒息新生儿脐血、恢复期血清中Ghrelin变化比Hs-CRP更能反应窒息严重程度。
Objective To investigate the dynamic changes of serum ghrelin and hs-CRP levels in neonates with asphyxia. Methods 40 cases of mild and severe neonatal asphyxia who were delivered from April 2010 to June 2011 in our hospital were selected as the observation group. Cord blood, acute phase (1-3 days) and convalescence (7-10 days) ) Serum Ghrelin and hs-CRP levels; select the same period of hospitalized asphyxia history of 40 healthy neonates as control group, cord blood Ghrelin and hs-CRP levels. Results The level of Ghrelin in asphyxia group decreased first and then increased with the course of disease. The acute phase [(22.1 ± 8.8) ng / ml] and convalescence period [(33.2 ± 12.2) ng / ml] / ml], recovery period is higher than the acute phase, the difference was statistically significant (P <0.05). The level of Ghrelin in cord blood of control group [(72.3 ± 15.6) mg / ml] was significantly higher than that of asphyxia group. The level of Ghrelin in cord blood of mild degree of asphyxia group was higher than that of severe asphyxia group. The level of hs-CRP in the asphyxia group increased first and then decreased with the course of the disease. The acute phase [(0.48 ± 0.22) mg / L] was higher than that in umbilical cord blood [(0.14 ± 0.11) mg / L] / L] is lower than the acute phase, the difference was statistically significant (P <0.05). The level of hs-CRP in cord blood of the control group was lower than that of asphyxia group [(0.02 ± 0.00) mg / L], while that of mild asphyxia group was lower than that of severe asphyxia group. There was no significant difference between cord blood and convalescence group and severe asphyxia group . Conclusions The levels of Ghrelin and hs-CRP are related to the occurrence and development of asphyxia. The changes of Ghrelin in cord blood of asphyxia neonates and convalescent serum reflect the severity of asphyxia more than that of Hs-CRP.