A Facile Strategy to Fabricate Polysaccharide-Based Magnetic Hydrogel Based on Enamine Bond

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Magnetic hydrogels have found extensive applications in fields such as soft robotics,drug delivery and shape morphing.Here a facile method was fabricated to prepare polysaccharide-based magnetic hydrogels.The chitosan-Fe3O4 ferrofluid was obtained by dispersing carboxyl groups modified Fe3O4 nanoparticles uniformly in chitosan matrix.Subsequently,the magnetic polysaccharide hydrogel was obtained by simply mixing cellulose acetoacetate solution with chitosan-Fe3O4 ferrofluid.The structures and properties of the magnetic hydrogel were analyzed using Fourier-transform infrared spectroscopy,rheological recovery,responsiveness,and stability measurements.The results indicated that magnetic polysaccharide hydrogel showed pH responsiveness and excellent self-healing properties,and the hydrogel manifested outstanding stability under physi-ological conditions(37 ℃)for 72 h.In addition,the injectable polysaccharide-based hydrogel exhibited sensitive magnetic responsive and shape-shifting ability under an external magnetic field.Therefore,the strategy for the facile preparation of the magnetic polysaccharide-based hydrogel in this work could provide a benign and versatile method for achieving self-healing,responsive,injectable properties for the application in biomedical fields.
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