论文部分内容阅读
目前两个第二代增敏剂对人都有着不同剂量限制的毒性,SR-2508引起外周神经毒,而Ro03-8799产生急性中枢神经毒,实验观察了两种增敏剂单独及合并用药的增敏作用.HRT18瘤取自人直肠腺癌,Na11+取自人黑色素瘤,3×10~6细胞分别注射于8～12周雌性裸鼠两侧腹部.为增加肿瘤接种率,实验前5Gy~(137)Csγ射线全身照射,剂量率2.88Gy/min,Na11+瘤直径9～10mm,HRT18瘤直径7～9mm,SR-2508和Ro03-8799溶于Dulbecco’s磷酸缓冲液(PBS),眼眶静脉窦注射,对照组注射PBS.照后立即杀死
At present, two second-generation sensitizers have different dose-limiting toxicities for humans, SR-2508 causes peripheral nerve toxicity, and Ro03-8799 produces acute central nervous system toxicity. Two sensitizers have been observed separately and combined for drug use. Sensitization. HRT18 tumors were taken from human rectal adenocarcinoma, Na11+ was from human melanoma, 3×10~6 cells were injected into the abdomen of female nude mice at 8 to 12 weeks, respectively. To increase the tumor inoculation rate, 5Gy~ before the experiment. (137) Whole-body Csγ-irradiation with a dose rate of 2.88 Gy/min, Na11+ tumor diameter of 9 to 10 mm, HRT18 tumor diameter of 7 to 9 mm, SR-2508 and Ro03-8799 dissolved in Dulbecco’s phosphate buffered saline (PBS), orbital sinus injection , The control group was injected with PBS. Immediately after the photo was taken