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新的4-喹诺酮类抗菌药物的主要作用机理是抑制细菌DNA转曲酶活性。包括氧氟沙星、环丙沙星、依诺沙星和诺氟沙星。这类药物比萘啶酮酸的活性高1000倍,且有更广的抗菌谱。耐药菌的产生率亦比较低。4-喹诺酮类药物是通过破坏细菌DNA结构而阻止细菌细胞分裂来杀菌的。环丙沙星和氧氟沙星除能抑制DNA转曲酶活性外,似乎还能破坏细菌的细胞膜,导致细胞内含物流失。这两种药物较其它的喹诺酮类药物活性高,且有更广的抗菌谱。人体细胞内含有与细菌转曲酶类似的酶。但据报道,喹诺酮类药物对人体内的这
The main mechanism of action of the new 4-quinolone antibacterial drugs is to inhibit bacterial DNA transglutaminase activity. Including ofloxacin, ciprofloxacin, enoxacin and norfloxacin. These drugs are 1,000 times more potent than nalidixic acid and have a broader antimicrobial spectrum. The incidence of drug-resistant bacteria is also relatively low. 4-Quinolones kill bacteria by disrupting bacterial cell division by disrupting bacterial DNA structures. Ciprofloxacin and ofloxacin in addition to inhibiting DNA transglutaminase activity, it seems that it can destroy the bacterial cell membrane, resulting in the loss of cellular contents. Both drugs are more active than other quinolones and have a broader antimicrobial spectrum. Human cells contain enzymes similar to bacterial translocase. However, quinolones are reported to be in the human body