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本文用放射免疫分析对64例NIDDM病人血浆心钠素、24小时尿微量白蛋白、血与尿β_2-微球蛋白进行测定,结果表明:糖尿病人血浆心钠素明显高于正常对照组(P<0.01),有早期糖尿病肾病者血浆心钠素显著高于无肾病者(P<0.01)。同时测定尿微量白蛋白、血β_2-微球蛋白及尿β_2-微球蛋白,均高于正常对照组(p<0.01,P<0.05)。提示糖尿病肾病早期血清β_2-微球蛋白及尿微量白蛋白,β_2-微球蛋白升高的同时伴随血浆心钠素升高。说明血浆心钠素的升高对糖尿病肾病早期诊断有一定临床意义。
In this paper, 64 cases of NIDDM patients with plasma atrial natriuretic peptide, 24-hour urine microalbumin, blood and urine β_2-microglobulin were measured by radioimmunoassay. The results showed that plasma atrial natriuretic peptide was significantly higher in diabetic patients than in normal control group (P <0.01). Plasma atrial natriuretic peptide in patients with early diabetic nephropathy was significantly higher than those without nephropathy (P <0.01). Simultaneous determination of urinary albumin, blood β_2-microglobulin and urinary β_2-microglobulin were higher than the normal control group (p <0.01, P <0.05). Prompted the early diabetic nephropathy serum β_2-microglobulin and urinary microalbumin, β_2-microglobulin increased accompanied by an increase in plasma atrial natriuretic peptide. Description of plasma atrial natriuretic peptide in the early diagnosis of diabetic nephropathy has some clinical significance.