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３１例经磺脲类（ＳＵ）口服降糖药治疗继发失效的非胰岛素依赖型糖尿病（ＮＩＤＤＭ） 患者，在足量ＳＵ药物的基础上联合应用芬氟拉明治疗。疗程为６周。结果显示：联合治疗前 后空腹血糖（ＦＢＧ）分别为：１２．０５±２．３８ｍｍｏｌ／Ｌ与８．３５±９．４３ ｍｍｏｌ／Ｌ，Ｐ＜０．００１；餐后血 糖（ＰＢＧ）分别为：１９．０６±５．４５ｍｍｏｌＬ与１３．１８±５．３７ｍｍｏｌ／Ｌ，Ｐ＜０．００１；糖基化血红蛋白 （ＨｂＡ１Ｃ）分别为：９．５１±２．４２％与６．６８±１．３１％。Ｐ＜０．００１。体块指数（ＢＭＩ）、空腹血浆胰 岛素（ＦＰＩ）及餐后血浆胰岛素（ＰＰＩ）均无明显改变。胰岛素敏感试验结果显示于治疗后各点 血糖水平均有不同程度下降。
Thirty-one patients with non-insulin-dependent diabetes mellitus (NIDDM) who underwent oral hypoglycemic agents with sulfonylurea (SU) for secondary failure were treated with fenfluramine in combination with sufficient SU agents. Treatment for 6 weeks. The results showed that fasting blood glucose (FBG) before and after combination therapy were 12.05 ± 2.38mmol / L and 8.35 ± 9.43 mmol / L, respectively, P <0.001; postprandial blood glucose (PBG) 19.06 ± 5.45mmolL and 13.18 ± 5.37mmol / L respectively, P <0.001; Glycosylated hemoglobin (HbA1C) was 9.51 ± 2.42% and 6.68 ± 1.31 %. P <0.001. Body mass index (BMI), fasting plasma insulin (FPI) and postprandial plasma insulin (PPI) had no significant changes. Insulin sensitivity test results showed that blood glucose levels decreased at various levels after treatment.