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在发展安全、有效的重组活病毒疫苗的过程中,低毒力和高免疫原性的痘苗病毒(VV)株是人们兴趣的焦点.作者比较了重组株和亲本株的毒力,并阐述了它与重组株免疫原性的关系.5个来自天花Sevac VARIE疫苗(pra-ha株)和3个来自Wyeth DRYVAX疫苗的
Low virulent and highly immunogenic vaccinia virus (VV) strains are of major interest in the development of safe and effective recombinant live virus vaccines.The authors compared the virulence of recombinant and parental strains and described Its relation to the immunogenicity of the recombinant strains Five from the VARV VARV VARV vaccine (pra-ha strain) and three from the Wyeth DRYVAX vaccine