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PET研究已证实精神分裂症患者脑纹状体代谢率的改变和抗精神病药物的影响有关。作者假设,纹状体代谢率异常减低的患者可能接受来自背盖中央区和黑质的过度的抑制性多巴能传入,抗精神病药阻断多巴胺能可使功能恢复正常;相反,没有这种抑制的患者纹状体代谢率正常,因而治疗后患者脑局部代谢和临床症状无改变。方法:对象为25例精神分裂症患者,男2例,女4例,平均年龄34.8±8.7岁,入组时BPRS分39.1±8.6,之前至少6周内未用长效抗精神病药。患者接受10周的双盲交叉
PET studies have confirmed that schizophrenia patients with changes in brain metabolic rate and antipsychotic effects. The authors hypothesized that patients with abnormally reduced striatal metabolic rate may receive an overdose of dopaminergic from the central area of the dorsal lid and substantia nigra for afferent function, whereas blockade of dopamine by the antipsychotic may restore function to normal; on the contrary, Inhibition of the striatum in patients with normal metabolic rate, and thus treatment of patients with local brain metabolism and clinical symptoms did not change. Methods: The subjects were 25 schizophrenics, 2 males and 4 females, with an average age of 34.8 ± 8.7 years. BPRS was 39.1 ± 8.6 at enrollment. Long-term antipsychotics were not used for at least 6 weeks. Patients received double-blind crossover for 10 weeks