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目的:研究侵袭性非霍奇金淋巴瘤并发纯红细胞再生障碍性贫血(PRCA)的临床特点和治疗结果。方法:报告两例分别并发于非特指型外周T细胞淋巴瘤(PTCL-NOS)和弥漫大B细胞淋巴瘤(DLBCL)的PRCA,并复习相关文献。结果:在联合化疗治疗后,DLBCL及其相关的PRCA均获完全缓解,而PTCL-NOS虽获缓解,但其相关的PRCA未好转,加用泼尼松治疗后PRCA缓解。结论:NHL相关的PRCA在联合化疗或免疫抑制治疗后可获完全缓解,且可不需维持治疗。
Objective: To investigate the clinical features and treatment of invasive non-Hodgkin’s lymphoma complicated with pure red cell aplasia (PRCA). METHODS: Two cases of PRCA were reported that were complicated by non-specific peripheral T-cell lymphoma (PTCL-NOS) and diffuse large B-cell lymphoma (DLBCL), respectively, and reviewed the relevant literature. Results: After combined chemotherapy, DLBCL and its related PRCA were completely relieved. Although PTCL-NOS was relieved, the related PRCA was not improved, and PRCA was relieved with prednisone. CONCLUSIONS: NHL-associated PRCA may be completely relieved after combination chemotherapy or immunosuppressive therapy without the need for maintenance treatment.