【摘 要】
：
In this paper, based on the known crystal structures of Square Pyramid (SP) and Trigonal Bipyramid (TBP) penta-coordinated phosphorus compounds containing amino
【机 构】
：
Key Lab of Bioorganic Phosphorus Chemistry and Chemical Biology of Ministry of Education
【基金项目】
：
清华大学校科研和教改项目;国家自然科学基金
论文部分内容阅读
In this paper, based on the known crystal structures of Square Pyramid (SP) and Trigonal Bipyramid (TBP) penta-coordinated phosphorus compounds containing amino acid side chains, such as amino, carboxyl, hydroxyl or thiol, a software designed to survey the P(5)-Structure of phosphorylated proteins. By this software, it was found that 382 of 398 phosphorus-related kinases (96%) from current PDB could go through the penta-coordinated phosphorus transition state or intermediate. For example, in protein 1HE8, amino group in Lysine16was within 3.58 A from the phosphorus atom, and a potential TBP structure consisting GNP2 and Nz could be overlapped with an authentic TBP with an RMSD value of 0.71 A.
其他文献
The elastic properties of syntactic foams with coated hollow spherical inclusions have been studied by means of Mori and Tanaka' s concept of average stress in
Highly oriented multiple boron nanowire nanojunctions with unilateral feather- like morphology were first successfully prepared using a radio-frequency magnetro
Au films with a thickness of about 300 nm were deposited on SiO2/Si(100) and mica substrates by dc sputtering. X-ray diffraction spectroscopy and field emission
Cu-Zn-A1 alloy of one dimensional nano-structure was prepared and the structure of obtained nano-material was characterized by transmission electron microscope
A parallel algorithm suitable for simulating multi-sized particle systems and multiphase fluid systems is proposed based on macro-scale pseudo-particle modeling
A computer system for displacement sensor is developed to obtain the real-time curve of the liquid porosity of molten Al alloy foam. The relationship between th
Tetranitrodiazidoacetylhexaazaisowurtzitane (TNDAIW) is a novel polyazapolycyclic caged polyazidonitramine explosive first synthesized in our laboratory. All of
The spin polarized β-emitting nuclei 12B (Iπ = 1+, T1/2 = 20.18 ms) were produced by the nuclear reaction 11B(d, p) 12B and by the selection technique of the
The activity model of CaO-FeO-SiO2-MoO3 quarternary system was established according to the coexistence theory of slag structure and the reduction thermodynamic
给出了无约束问题的一种新方法--平面上的黄金分割法,这是一种直接解法,该方法是一维搜索中的0.618法在平面上的推广,无需计算函数的导数,仅需计算函数值既可.此外,本法克服