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目的调查十堰地区恶性肿瘤患者的隐孢子虫感染情况及流行特点,为恶性肿瘤患者隐孢子虫感染的防治提供依据。方法采集十堰市太和医院217例恶性肿瘤患者粪便,采用金胺酚+改良抗酸染色法检查隐孢子虫卵囊。结果 217例肿瘤患者隐孢子虫感染率为48.85%,男性患者与女性患者隐孢子虫感染率分别为49.58%和47.96%,差异无统计学意义(P>0.05);化疗、放疗、化疗+放疗患者隐孢子虫感染率分别为38.46%、37.88%和69.86%,差异有统计学意义(P<0.01);不同类别的肿瘤患者的隐孢子虫感染率分别是:呼吸系统为37.50%、消化系统为60.78%、乳腺为38.89%、其他(包括脑瘤、肾上腺瘤、甲状腺瘤等)为40.00%,差异有统计学意义(P<0.01)。结论恶性肿瘤患者易发生隐孢子虫感染,可能与其机体的免疫功能下降有关。
Objective To investigate the prevalence and epidemiological characteristics of cryptosporidiosis in patients with malignant tumors in Shiyan and to provide basis for the prevention and treatment of cryptosporidiosis in patients with malignant tumors. Methods A total of 217 cases of malignant tumor in Taihe Hospital of Shiyan City were collected. Cryptosporidium oocysts were detected by ammine + modified acid - fast staining. Results The infection rates of Cryptosporidium in 217 cases were 48.85%. The infection rates of Cryptosporidium in male and female patients were 49.58% and 47.96% respectively, with no significant difference (P> 0.05). Chemotherapy, radiotherapy, chemotherapy and radiotherapy The infection rates of Cryptosporidium were 38.46%, 37.88% and 69.86% respectively, with significant difference (P <0.01). The infection rates of Cryptosporidium in different types of cancer patients were: respiratory system was 37.50%, digestive system 60.78% and 38.89% in breast. The others (including brain tumor, adrenal tumor and thyroid tumor) were 40.00%, the difference was statistically significant (P <0.01). Conclusions Cryptosporidium infection is likely to occur in patients with malignant tumors, which may be related to the decline of immune function.