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２０只糖尿病和１０只正常中国地鼠配对，随机分为４组：正常对照组（Ｃ）、糖尿病组（Ｄ）、正常用锂处理组（ＣＴ）和糖尿病用锂处理组（ＤＴ）。锂处理为动物饮用含碳酸锂２８．８ｍｍｏｌ／Ｌ的水，在０，１，３，５，６月测定血糖，在１，３，６月测定胰岛素水平。实验结束时处死动物取组织经湿消化后，用电感耦合等离子体－原子发射光谱仪（ＩＣＰ－ＡＥＳ）测定锂含量。同时测定血果糖胺、乳酸、ＧＰＴ和ＢＵＮ。结果：Ｄ组肝锂含量显著低于Ｃ组（Ｐ＜０．０５），肾与肌肉的锂含量也降低。ＤＴ组组织锂含量较Ｄ组高，与Ｃ组相似，且血糖与果糖胺下降，而胰岛素、乳酸、ＧＰＴ和ＢＵＮ无明显变化。实验表明糖尿病中国地鼠（山医群）有肝、肾和肌肉缺锂。小剂量６个月的锂处理能改善组织缺锂和糖代谢，对肝肾无明显损害
Twenty diabetes mellitus and 10 normal Chinese hamsters were matched and randomly divided into 4 groups: normal control group (C), diabetic group (D), normal lithium treatment group (CT) and diabetic lithium treatment group (DT). Lithium treatment for animal consumption of lithium carbonate containing 28.8mmol / L of water, measured in 0, 1, 3, 5, 6 months of blood glucose, measured insulin levels in January, March and June. Animals were sacrificed at the end of the experiment. After wet digestion, the lithium content was determined by inductively coupled plasma atomic emission spectrometry (ICP-AES). Blood fructosamine, lactate, GPT and BUN were also measured simultaneously. Results: The liver lithium content in group D was significantly lower than that in group C (P <0.05), and the lithium content in kidney and muscle was also decreased. The content of lithium in group DT was higher than that in group D, similar to group C, and the blood glucose and fructosamine decreased. Insulin, lactate, GPT and BUN had no significant changes. Experiments show that diabetes Chinese hamster (Yamai group) liver, kidney and muscle lithium deficiency. Small doses of 6 months of lithium treatment can improve tissue lithium and glucose metabolism, liver and kidney no significant damage