论文部分内容阅读
目的研究阿托伐他汀对不稳定型心绞痛患者冠脉炎症的影响,不同剂量阿托伐他汀的作用是否不同。方法将不稳定型心绞痛患者共232例,分为服用阿托伐他汀10mg/d、20mg/d、40mg/d和对照组共4组,分别测定治疗前和治疗3个月、6个月血中CRP和IL-6的浓度变化,评估阿托伐他汀对不稳定型心绞痛患者冠脉炎症的作用。结果阿托伐他汀各治疗组与对照组相比,均能明显降低CRP,其中大剂量阿托伐他汀降低CRP更明显,与其他各组相比差异有统计学意义;阿托伐他汀对IL-6的影响不大。结论早期大剂量使用阿托伐他汀能有效控制不稳定型心绞痛患者的冠脉炎症,控制程度与阿托伐他汀的使用剂量成正比。
Objective To investigate the effect of atorvastatin on coronary artery inflammation in patients with unstable angina and whether different doses of atorvastatin have different effects. Methods A total of 232 patients with unstable angina pectoris were divided into 4 groups: atorvastatin 10mg / d, 20mg / d, 40mg / d and control group. Before treatment, 3 months and 6 months of treatment To assess the effect of atorvastatin on coronary inflammation in patients with unstable angina pectoris following changes in the concentrations of CRP and IL-6. Results Atorvastatin treatment group compared with the control group, can significantly reduce CRP, including high-dose atorvastatin CRP was more obvious, compared with the other groups, the difference was statistically significant; atorvastatin IL -6 little effect. Conclusion Early high-dose atorvastatin can effectively control coronary artery inflammation in patients with unstable angina, the degree of control is proportional to the dose of atorvastatin.