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目前体外受精·胚胎移植(IVF-ET)已成为治疗不孕症的重要新技术。日本自1983年开展这一方法,现已遍及全国156个机构,仅1990年就有1000例获得妊娠,但其流产发生率亦较高。为提高效率,现就IVF-ET与流产率、流产时间及母体年龄等的关系作一介绍。1.流产率1990年日本全国共有5277的患者接受IVF-ET,ET妊娠率20.1%,流产率30.9%;名古屋大学医学部附院妇产科在1985～1992年,共施行IVF-ET614例,ET妊娠率30%,流产率25%。1990年美国报告ET妊娠率21.6%,流产率21.8%,且此数字不包括化学性流产。而自然妊娠流产率仅10%左右,可见IVF-ET后流产发生率是较高的。2.流产时间IVF-ET后妊娠6周内流产病例约占全部流产病例的48.8%,此系因为早孕时期化学性流产发生率较高之故。其中60%是由于染色体异常所致。随着妊娠时间增加,发生流产例数逐渐减少,但亦难否
In vitro fertilization and embryo transfer (IVF-ET) has become an important new technology in the treatment of infertility. Japan has carried out this method since 1983 and now has 156 institutions across the country. In 1990 alone, 1,000 pregnancies were obtained but the incidence of miscarriage was also high. In order to improve the efficiency, we introduce the relationship between IVF-ET and abortion rate, abortion time and maternal age. 1. Abortion rate In 1990, a total of 5277 patients in Japan received IVF-ET. The pregnancy rate was 20.1% and the abortion rate was 30.9%. The obstetrics and gynecology department of the Affiliated Hospital of Nagoya University from 1985 to 1992 performed IVF- Pregnancy rate 30%, abortion rate 25%. In 1990, the United States reported an ET pregnancy rate of 21.6% and a miscarriage rate of 21.8%, and this figure does not include chemical abortion. The spontaneous pregnancy miscarriage rate was only about 10%, we can see the incidence of abortion after IVF-ET is higher. Abortion time IVF-ET 6 weeks after pregnancy, abortion cases accounted for about 48.8% of all cases of abortion, this is because of the high incidence of chemical abortion during early pregnancy. 60% of them are due to chromosomal abnormalities. With the increase of pregnancy time, the number of cases of abortion gradually decreases, but it is also hard to decide whether to abort