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提出了Fe2+-H2O2-亚甲基蓝化学发光新体系并用于阿魏酸钠的测定。实验发现,在酸性介质中,Fe2+-H2O2体系可与亚甲基蓝反应产生极强的化学发光,阿魏酸钠对此化学发光具有显著的抑制作用。据此,结合流动注射技术,建立了阿魏酸钠化学发光分析新方法。研究了影响化学发光强度的因素,化学发光信号的降低值(ΔI)与阿魏酸钠浓度在4.5×10-6～4.5×10-5mol/L范围内呈良好的线性关系,方法的检出限为7.0×10-7mol/L。对4.8×10-6mol/L的阿魏酸钠进行了11次平行测定,其RSD=0.8%,该法已用于片剂中阿魏酸钠含量的测定。
A novel chemiluminescence system of Fe2+-H2O2-methylene blue was proposed and used for the determination of sodium ferulate. It was found that Fe2+-H2O2 system can react with methylene blue to produce strong chemiluminescence in acidic medium. Sodium ferulate has a significant inhibitory effect on this chemiluminescence. Based on this, a new method of chemiluminescence analysis of sodium ferulate was established based on the flow injection technique. The factors affecting the intensity of chemiluminescence were studied. The linear relationship between the decrease of chemiluminescence signal (ΔI) and the concentration of sodium ferulate in the range of 4.5×10-6 to 4.5×10-5 mol/L was found. The limit is 7.0×10-7 mol/L. A parallel determination of 4.8×10 −6 mol/L sodium ferulate was performed 11 times with an RSD of 0.8%. This method has been used for the determination of sodium ferulate in tablets.