论文部分内容阅读
目的:寻求预测子宫内膜异位症(EMs)相关卵巢癌恶变的方法。方法:采用病例-对照研究的方法,以21例卵巢子宫内膜异位症恶变患者为病例组,以45例卵巢内膜样囊肿患者为对照组,分析卵巢子宫内膜异位症恶变患者的病史特点、血清CA125水平、超声学改变。结果:病例组中囊壁见乳头或血流丰富者显示多于对照组,组间差异有统计学意义(P<0.05);囊肿直径>8 cm的恶变风险OR=8.7(95%CI=2.6~29.3,P<0.001);CA125>200 IU/ml的恶变风险OR=2.3,但差异无统计学意义(95%CI=0.4~12.7,P=0.33);病程>5年的恶变风险OR=1.3(95%CI=0.4~4.3,P=0.72),囊肿超声见分隔或囊肿周围粘连在病例组和对照组中差异无统计学意义(P>0.05)。结论:囊壁有乳头或囊壁见血流、囊肿直径>8 cm为恶变的高危因素;CA125>200 IU/ml、病程>5年可能是恶变的高危因素,但不能有效预测恶变的发生。
Objective: To find a method to predict the malignant transformation of ovarian cancer associated with endometriosis (EMs). Methods: A case-control study was conducted in 21 patients with malignant ovarian endometriosis and 45 patients with ovarian endometrioid cyst as control group. The patients with malignant ovarian endometriosis History of the characteristics of serum CA125 levels, ultrasound changes. Results: There were more papillary or pleural effusion in the case group than in the control group, the difference was statistically significant (P <0.05). The risk of malignant transformation of cyst> 8 cm in diameter was OR = 8.7 (95% CI = 2.6 ~ 29.3, P <0.001). The risk of malignant transformation of CA125> 200 IU / ml was 2.3, but the difference was not statistically significant (95% CI = 0.4-12.7, P = 0.33) 1.3 (95% CI = 0.4 ~ 4.3, P = 0.72). There was no significant difference between the cases and the control group in cyst ultrasound or cyst adhesion (P> 0.05). CONCLUSION: There is blood flow in the wall of papillary or cystic wall. The diameter of cyst> 8 cm is the risk factor for malignant transformation. CA125> 200 IU / ml and duration> 5 years may be the risk factors of malignant transformation, but can not effectively predict the malignant transformation.