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小鼠接种突变的p53细胞后,给予逆转录病毒野生型p53表达载体可大大地减少小鼠发生肺癌的百分率.Fujiwara等推断矫正基因异常可抑制人类的带有异常p53表达的肺癌细胞的生长.
Mice inoculated with mutated p53 cells were treated with retroviral wild-type p53 expression vector to significantly reduce the percentage of lung cancer in mice. Fujiwara et al. concluded that corrected gene abnormalities can inhibit the growth of human lung cancer cells with abnormal p53 expression.