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[目的]观察消瘤汤联合奥沙利铂、5-氟尿嘧啶治疗胃肠道肿瘤疗效。[方法]使用随机平行对照方法,将62例住院患者随机分为两组。对照组31例奥沙利铂130mg/m2,静滴2h,d1;5-氟尿嘧啶250mg/d,静注,d1-5。治疗组31例消瘤汤(茯苓、白术各10g,炒谷芽15g,三棱、姜半夏、扁豆、莪术、佛手、陈皮、麦冬各10g,马齿苋、薏仁、白花蛇舌草各30g,炒麦芽15g,人参5g,砂仁3g;恶心呕吐酌加干姜、姜半夏;腹泻加山药、吴茱萸;疼痛较甚酌加延胡索、白芍;胃阴不足酌加麦冬、玄参;舌苔厚腻酌加黄连、厚朴;脾肾阳虚酌加杜仲、菟丝),水煎300m L,早晚分服;奥沙利铂、5-氟尿嘧啶西药治疗同对照组。连续治疗21d为1疗程。观测临床症状、瘤体大小、生存质量、不良反应。治疗1疗程,判定疗效。[结果]实体瘤疗效:治疗组完全缓解16例,部分缓解8例,稳定5例,进展2例,总有效率77.42%;对照组完全缓解4例,部分缓解5例,稳定15例,进展7例,总有效率29.03%;治疗组优于对照组(P<0.05)。生存质量评分,治疗组改善19例,稳定8例,下降4例,总有效率77.42%;对照组改善9例,稳定7例,下降15例,总有效率29.03%,治疗组优于对照组(P<0.05)。不良反应治疗组低于对照组(P<0.05)。[结论]消瘤汤联合奥沙利铂、5-氟尿嘧啶治疗胃肠道肿瘤,疗效满意,不良反应发生率低,值得推广。
[Objective] To observe the curative effect of Xiaoyu decoction combined with oxaliplatin and 5-fluorouracil on gastrointestinal tumors. [Methods] Sixty-two inpatients were randomly divided into two groups using randomized parallel control. Control group, 31 cases of oxaliplatin 130mg / m2, intravenous drip 2h, d1; 5 - fluorouracil 250mg / d, intravenous injection, d1-5. In the treatment group, 31 cases of Xiaoyu Soup (Poria, Atractylodes each 10g, fried Guya 15g, Sanleng, ginger Banxia, lentils, Curcuma, bergamot, dried tangerine peel, Radix every 10g, purslane, Fried malt 15g, ginseng 5g, Amomum 3g; nausea and vomiting, add ginger, ginger Banxia; diarrhea plus yam, Evodia; pain more discretion plus corydalis, white peony root; Dispensing Coptis, Magnolia; spleen and kidney yanguang plus Eucommia, reeling), decoction 300m L, morning and evening service; oxaliplatin, 5-fluorouracil western medicine treatment with the control group. Continuous treatment of 21d for a course of treatment. Observation of clinical symptoms, tumor size, quality of life, adverse reactions. Treatment of a course of treatment to determine the efficacy. [Results] The curative effect of solid tumor: The treatment group completely relieved 16 cases, partially relieved 8 cases, stable 5 cases, progress 2 cases, the total effective rate 77.42%; control group 4 cases completely relieved, partial relief 5 cases, stable 15 cases, progress 7 cases, the total effective rate was 29.03%. The treatment group was better than the control group (P <0.05). The quality of life in the treatment group improved in 19 cases, stable in 8 cases, decreased in 4 cases, the total effective rate was 77.42%; the control group improved in 9 cases, stable in 7 cases, decreased in 15 cases, the total effective rate was 29.03% (P <0.05). Adverse reactions in the treatment group were lower than those in the control group (P <0.05). [Conclusion] Xiaoyu decoction combined with oxaliplatin and 5-fluorouracil in the treatment of gastrointestinal cancer has satisfactory curative effect and low incidence of adverse reactions, which deserves promotion.