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一、—些优缺点对接触诱变因子的个体和培养细胞的研究业已表明,对离体和活体内诱发的染色体结构改变,人体外周血淋巴细胞是一个非常敏感的指示物。染色体结构的这些变化是遗传物质损伤的一个很容易观察的形态学指征。尽管从离体结果外推至活体的情况还存在一些问题,但是淋巴细胞作为一种测定系统有如下几个优点: (1) 很容易获得大量的人体细胞:从一个人身上很容易连续多次采集到几ml外周血,每1ml血就可
Some Advantages and Disadvantages Studies of individuals and cultured cells that have been exposed to mutagenic agents have shown that human peripheral blood lymphocytes are a very sensitive indicator of structural changes induced in vitro and in vivo. These changes in chromosomal structure are a readily observable morphological indicator of genetic material damage. Although there are some problems with extrapolation of ex vivo results to living organisms, lymphocyte as a measurement system has the following advantages: (1) It is easy to obtain a large amount of human cells: it is easy to be continuously repeated from one person to another Collect a few ml of peripheral blood, every 1ml of blood can be