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异常血红蛋白病是由于血红蛋白分子结构异常而引起的一种常见的遗传性分子病。据世界卫生组织(WHO)估计,全世界携带异常血红蛋白基因的人有一亿多人,列为世界六大疾病之一。1980年,我国十七个省、市、自治区对123,437名汉、蒙、回、满、苗、黎、维吾尔、哈萨克等二十个民族进行血红蛋白病普查结果,发现血红蛋白病315例,发现率为2.55‰。但对于畬族中异常血红蛋白的发病情况至今未见报道。我们于1981年7月首次对浙江省丽水县2,304名畬族人进行了异常血红蛋白病的普查,现报道如下:
Abnormal hemoglobinopathy is a common genetic molecular disease caused by structural abnormalities of hemoglobin. According to the World Health Organization (WHO), more than 100 million people worldwide carry abnormal hemoglobin genes, making them one of the six major diseases in the world. In 1980, 123,437 Chinese, Mongolian, Hui, Manchu, Li, Uyghur, Kazakh and other 20 nationalities were surveyed by hemoglobinopathies in 20 provinces and municipalities in China. 315 hemoglobinopathies were found, with a detection rate of 2.55 ‰. However, the incidence of abnormal hemoglobin She has not been reported so far. For the first time in July 1981, we conducted a survey of 2,304 She people in Lishui County, Zhejiang Province, and we now report the following: