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目的:比较补阳还五汤中单味中药的有效部位重组液(B液)与补阳还五汤复方水煎液(A液)的药理作用,同时探讨补阳还五汤治疗半身不遂的作用机制。方法:本文采用凝血酶原时间、凝血时间和小鼠断头后张口喘气时间等3个药理指标,研究补阳还五汤用传统的水煎制备的A液和单味中药分别提取有效部位后重组的B液,分别进行上述药理指标的比较研究。结果:A液和B液对凝血酶原时间犤A液:高剂量组(16.65±0.54)s,中剂量组(17.27±0.64)s,低剂量组(15.80±0.88)s;B液:高剂量组(23.50±2.84)s,中剂量组(24.74±2.41)s,低剂量组(24.63±3.29)s犦、凝血时间犤A液:高剂量组(41.06±3.25)s,中剂量组(50.93±14.77)s,低剂量组(50.79±15.83)s;B液:高剂量组(45.07±4.37)s,中剂量组(56.40±8.78)s,低剂量组(53.98±12.41)s犦和小鼠断头后张口喘气时间犤A液:高剂量组(24.91±0.60)s,中剂量组(24.69±0.58)s,低剂量组(23.83±0.80)s;B液:高剂量组(24.59±0.60)s,中剂量组(24.89±0.45)s,低剂量组(24.56±0.48)s犦,均有明显的延长作用,与对照组比差异有显著意义(t=2.259～13.463,P<0.05～P<0.01),而且B液的作用比A液明显(t=2.265～9.479,P<0.05～P<0.01)。结论:①补阳还五汤单味中药有效部位重组液的药理作用比复方水煎液强。②提示?
OBJECTIVE: To compare the pharmacological effects of effective fraction reconstituted liquid (B liquid) and Buyang Huanwu decoction decoction (A liquid) in Buyang Huanwu Decoction, and to explore the effect of Buyang Huanwu Decoction in treating hemiplegia. mechanism. METHODS: Three pharmacological parameters including prothrombin time, coagulation time, and gasping time after decapitation were used to study the effect of A liquid extracted from traditional Chinese decoction and the single-taste Chinese herbal medicine after extracting the active site. Recombinant B fluids were subjected to comparative studies of the above pharmacological parameters, respectively. RESULTS: The time of prothrombin time in solution A and B was 犤A: high dose (16.65±0.54) s, middle dose (17.27±0.64) s, low dose (15.80±0.88) s; B fluid: high Dose group (23.50±2.84)s, middle dose group (24.74±2.41)s, low dose group (24.63±3.29)s, coagulation time 犤A fluid: high dose group (41.06±3.25)s, middle dose group ( 50.93±14.77)s, low dose group (50.79±15.83)s; B fluid: high dose group (45.07±4.37) s, middle dose group (56.40±8.78) s, low dose group (53.98±12.41) s and After the decapitation of the mice, the duration of panting time was as follows: high-dose group (24.91±0.60) s, middle-dose group (24.69±0.58) s, low-dose group (23.83±0.80) s; B fluid: high-dose group (24.59 ± 0.60) s, moderate dose (24.89 ± 0.45) s, low dose (24.56 ± 0.48) s, all had significant prolongation, and there was significant difference from the control group (t = 2.259 ~ 13.463, P < 0.05-P<0.01), and the effect of liquid B was significantly greater than that of liquid A (t=2.265-9.479, P<0.05-P<0.01). Conclusion:1 The pharmacological action of the reconstituted liquid in the effective fraction of single Chinese herb of Buyang Huanwu Decoction is stronger than that of compound decoction. 2 tips?