目的研究酮替芬对哮喘患儿茶碱药代动力学的影响。方法应用高效液相色谱仪测定茶碱血浓度，对１２例哮喘患儿单用氨茶碱和氨茶碱加酮替芬后两组茶碱药代动力学参数及浓度进行对照观察。结果加用酮替芬后，血清茶碱最高浓度降低２０１％，清除速率常数和清除率分别增加２４１％和５３７％，曲线下面积减少３２９％，清除半衰期缩短２４９％。结论酮替芬、氨茶碱相互作用可能增强茶碱治疗哮喘的安全性和有效性 Objective To investigate the effect of ketotifen on pharmacokinetics of theophylline in children with asthma. Methods The plasma concentrations of theophylline were determined by HPLC. The pharmacokinetic parameters and concentrations of theophylline in 12 asthmatic children after aminophylline and aminophylline plus ketotifen were compared. Results After ketotifen addition, the highest concentration of serum theophylline was reduced by 201%, the clearance rate and clearance rate were increased by 241% and 537% respectively, the area under the curve decreased by 329% and the elimination half-life was shortened by 24 ⑨ 9%. Conclusions Ketotifen and aminophylline may enhance the safety and efficacy of theophylline in the treatment of asthma