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[目的]探讨胰腺癌组织中淋巴管密度与肿瘤恶性程度、淋巴转移的相关性。[方法]应用免疫组化方法,采用单克隆抗体D2-40检测经手术切除的33例胰腺癌组织的瘤周淋巴管密度(pLVD)和瘤内淋巴管密度(iLVD),分析胰腺癌组织pLVD、iLVD与患者临床病理参数之间的关系。[结果]胰腺癌的pLVD明显高于iLVD。胰腺癌的pLVD与肿瘤的分化程度、淋巴结转移及淋巴管累及明显相关,与年龄、性别、肿块大小、发生部位、浸润侵犯无关。[结论]胰腺癌中检测pLVD较iLVD更有价值;上述pLVD可以预测淋巴结转移,有助于判断预后。
[Objective] To investigate the correlation between lymphatic vessel density and malignant degree of tumor and lymphatic metastasis in pancreatic cancer. [Methods] Immunohistochemical method was used to detect the peri-lymphatic vessel density (pLVD) and lymphatic vessel density (iLVD) in 33 cases of pancreatic cancer resected by monoclonal antibody D2-40. The expression of pLVD , ILVD and clinicopathological parameters of the relationship between. [Results] The pLVD of pancreatic cancer was significantly higher than that of iLVD. The pLVD of pancreatic cancer was significantly correlated with the degree of tumor differentiation, lymph node metastasis and lymphatic involvement, but not with age, sex, tumor size, site of invasion, infiltration. [Conclusion] The detection of pLVD in pancreatic cancer is more valuable than iLVD; the above pLVD can predict the lymph node metastasis and help to judge the prognosis.