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患者男性,48岁,莆田人,农民,已婚,于1963年5月17日入院。患者于入院半年前始感左鼻腔堵塞,偶有血性鼻涕流出,同时,左眼上下睑中部各长一黑色之肿物,迅速增大,一个月后,达龙眼核大小,在乡村某保健院行左上下眼睑肿物摘除术,但鼻塞及血性鼻涕仍继续加重,遂来院治疗。体检可见左眼上下睑中部各有一小瘢痕,约1厘米大小。左鼻腔充满黑色块状物,前方有部分坏死,呈灰白色,该肿物中等硬度,触之易出血,四周复盖脓性分泌物。心、肺、腹均未见异常。血、尿常规检查均正常。副(?) X 线摄片可见左侧上颌窦之透明度减低。临床诊断:为眼睑及鼻腔多发性恶性黑色素瘤。于5月28日手术取出左鼻腔肿物。病理报告:为柱状上皮或小梭形上皮肿瘤细胞组织,细胞多呈(氵弥)漫性浸润,有些细胞内含有色素,并且细胞间色素沉着。部分肿瘤组织坏死及炎症细胞浸润。病理诊断:为鼻腔恶性黑色素瘤。
The patient was male, 48 years old, was from Putian, farmer, married and was admitted on May 17, 1963. The patient first felt left nasal blockage six months before admission, and sometimes had bloody epistaxis. At the same time, the left and right eyes had a black mass that quickly grew in size. One month later, the size of the Dalong eye was found in a village hospital. Left upper and lower eyelid tumors were removed, but nasal congestion and bloody nose continued to worsen. Physical examination revealed a small scar in the middle of the left and right eyes, about 1 cm in size. The left nasal cavity is full of black lumps, with some necrosis in the front and grayish white. This tumor is of equal hardness, easily bleeding, and covered with purulent secretions. No abnormalities were found in heart, lung and abdomen. Routine blood and urine tests were normal. The deputy (?) X radiography showed a decrease in the transparency of the left maxillary sinus. Clinical diagnosis: Multiple malignant melanoma of the eyelids and nasal cavity. On May 28, a left nasal mass was surgically removed. Pathology report: columnar epithelium or small spindle-shaped epithelial tumor cell tissue, cells were mostly diffuse infiltration, some cells contained pigment, and intercellular pigmentation. Some tumor tissue necrosis and inflammatory cell infiltration. Pathological diagnosis: malignant melanoma of the nasal cavity.