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青年型胰岛素依赖性糖尿病(IDDM)是一种有家族倾向的常见病,其遗传方式尚未完全明了,可能是一组异质性的疾病。作者于20％以上的IDDM病人中检出一种少见的共显性遗传特征,为Bf位点的等位基因,与主要组织相容性复合物(HLA)密切相关。这一发现有利于检出未外显的携带者,和进行深入的遗传学分析研究。作者检查分析了106例IDDM患者和无糖尿病对照组262例的血清或血浆;同时研究了6例先证者的家庭,9个单有先证者的家庭中无糖尿病同胞和4个有多人发病的先证者家庭中有糖尿病同胞。
Adolescent insulin-dependent diabetes mellitus (IDDM) is a common family-predisposed disease whose inheritance has not yet been fully understood and may be a heterogeneous group of diseases. The authors identified a rare co-dominant genetic signature in more than 20% of IDDM patients as alleles of the Bf locus that are closely related to the major histocompatibility complex (HLA). This finding facilitates the detection of unobserved carriers and in-depth genetic analysis. The authors examined and analyzed 106 cases of IDDM patients and non-diabetic control group of 262 cases of serum or plasma; at the same time studied the 6 probands families, 9 probands without diabetes in the family and 4 more people The incidence of proband family with diabetic siblings.