作者首次采用5-氨基水杨酸(5-ASA)栓剂维持治疗远端溃疡性结肠炎,进行1年随机、双盲、安慰剂对照临床试验,并对长期应用该药的副作用及患者的顺应性进行了估价。经临床、内镜及组织学证实为远端溃疡性结肠炎患者30例(直肠炎17例、直肠乙状结肠炎13例)列入本研究,均未用类固醇至少1个月,现处于完全缓解。将患者随机分为两组,给予5-ASA栓剂或安慰剂400mg, The authors first used 5-aminosalicylic acid suppositories (5-ASA) suppository treatment of distal ulcerative colitis, a one-year randomized, double-blind, placebo-controlled clinical trials, and long-term use of the drug side effects and patient compliance Sex was evaluated. Thirty patients with distal ulcerative colitis (17 proctitis and 13 rectosigmoiditis) were confirmed by clinical, endoscopic and histological studies. No steroids were used for at least one month and are in complete remission. Patients were randomized to receive either 5-ASA suppository or placebo 400 mg,