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用阿霉素脂质体与碘油混合后对大经导管肝动脉栓塞，用反相高效液相色谱法研究了阿霉素在犬体内的分布及药代动力学。结果显示，阿霉素脂质体－碘油栓塞组大血浆阿霉素浓度显著低于阿霉素灌注组（P＜0.01）和阿霉素－碘油栓塞组（P＜0．05），而其血浆阿霉素消除半衰期和肝组织中阿霉素浓度与后两组相比则显著增加（p＜0．01及p＜0．05）。说明阿霉素脂质体与碘油混合肝动脉栓塞后可显著提高阿霉素对肝脏的靶向性，延长阿霉素消除半衰期．
With doxorubicin liposome mixed with lipiodol after transcatheter arterial embolization, using reverse-phase high performance liquid chromatography in doxorubicin distribution in dogs and pharmacokinetics. The results showed that the doxorubicin concentration in doxorubicin-lipiodol embolization group was significantly lower than that in doxorubicin group (P <0.01) and doxorubicin-iodized oil embolization group (P <0.05) The plasma half-life of doxorubicin and doxorubicin in liver tissue were significantly increased compared with the latter two groups (p <0.01 and p <0.05). Adriamycin liposomes and lipiodol mixed hepatic artery embolization can significantly improve the targeting of doxorubicin on the liver and extend the elimination half-life of doxorubicin.