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热熔挤出技术在提高难溶性药物溶出度方面具有的突出优势,具有工艺简单、连续化操作、生产效率高和在线监测等优点,已成为国外制备固体分散体的主导技术,显示出独特的优势和应用潜力。现浅述热熔挤出技术的原理和提高药物溶解度的机制,以深化人们对热熔挤出技术的了解。
Hot melt extrusion technology in improving the dissolution of insoluble drugs has outstanding advantages, with a simple process, continuous operation, high production efficiency and on-line monitoring, has become the leading foreign solid dispersion preparation technology, showing a unique Advantages and potential applications. Now the principle of hot melt extrusion technology and improve the mechanism of drug solubility in order to deepen people’s understanding of hot melt extrusion technology.