论文部分内容阅读
目的 评价PCNA在判断胃良性病变恶性趋势中的诊断价值,同时对癌前病变从细胞动力学角度做一些初步探讨。方法 应用PCNA免疫组化染色观察PCNA在胃粘膜异型增生、肠上皮化生、单纯再生粘膜以及正常粘膜和癌性上皮中的表达情况。结果 在胃正常粘膜、单纯再生及肠上皮化生组织中PCNA阳性表达较低,在异型增生组织中阳性表达明显增加(P<0.05)。结论 从细胞增殖动力学角度,提示胃粘膜异型增生是胃癌前期高危病变。PCNA可较客观地反映胃粘膜组织在各种病理状态下的生物学行为,作为辅助手段,具有一定临床指导作用。
Objective To evaluate the diagnostic value of PCNA in judging the malignant trend of benign gastric lesions. At the same time, preliminary studies are made on the precancerous lesions from the perspective of cell dynamics. Methods PCNA immunohistochemical staining was used to observe the expression of PCNA in gastric mucosal dysplasia, intestinal metaplasia, regenerated mucosa, normal mucosa and cancerous epithelium. Results The positive expression of PCNA was lower in normal gastric mucosa, pure regeneration, and intestinal metaplasia, and the positive expression was significantly increased in dysplasia (P<0.05). Conclusion From the perspective of cell proliferation kinetics, it is suggested that gastric dysplasia is a high-risk lesion of precancerous gastric lesions. PCNA can objectively reflect the biological behavior of gastric mucosa under various pathological conditions. As an aid, PCNA has certain clinical guidance.