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目的:观察人参健心胶囊对阿霉素所致心衰大鼠神经内分泌系统的影响。方法:采用持续腹腔注射阿霉素法,每周1次,共6周,制造慢性充血性心衰大鼠模型,第5周开始每日灌服中药寒凉剂共7 d。将50只大鼠随机分为正常组、模型组(生理盐水)、卡托普利组(12.5 mg.kg-1)、人参健心胶囊低、高剂量组(1.92,3.83 g.kg-1),给药2周后检测大鼠血液内皮素、白介素6、血管紧张素Ⅱ水平、一氧化氮水平、肿瘤坏死因子的变化,大鼠心重指数和心肌标本HE病理染色,观察人参健心胶囊对慢性心衰大鼠神经内分泌系统及大鼠心肌细胞形态学的影响。结果:与正常组比较,模型组大鼠心脏质量(P<0.05)、左心室质量(P<0.01)、左心室指数(LVW/BW)和心重指数(HW/BW)明显增加(P<0.01);与模型组比较,人参健心胶囊可显著降低慢性心衰大鼠全心指数(P<0.01)和左心室指数(P<0.01),降低血管内皮素(P<0.01)、白介素6(P<0.01)、血管紧张素Ⅱ(P<0.01)和一氧化氮水平(P<0.01),且中药高剂量组优于中药低剂量组(P<0.01)。人参健心胶囊可减轻心肌细胞变性和炎细胞浸润,具有心肌保护作用。结论:人参健心胶囊可改善阿霉素诱导的心衰大鼠的左室心肌肥厚,可能通过调节神经内分泌系统发挥作用,并对阿霉素导致的心肌损害起保护修复作用。
Objective: To observe the effects of ginseng Jianxin Capsule on the neuroendocrine system in rats with adriamycin-induced heart failure. Methods: The rat model of chronic congestive heart failure was established by continuous intraperitoneal injection of doxorubicin once a week for 6 weeks. 50 rats were randomly divided into normal group, model group (saline), captopril group (12.5 mg.kg-1), ginseng Jianxin capsule low and high dose group (1.92, 3.83 g.kg-1 ). The blood levels of endothelin, interleukin 6, angiotensin II, nitric oxide, tumor necrosis factor, rat heart index and myocardial tissue HE staining were measured at 2 weeks after administration. The effects of ginseng Jianxin Capsule Effects of Neuroendocrine System and Cardiomyocyte Morphology in Chronic Heart Failure Rats. Results: Compared with the normal group, the left ventricular mass and left ventricular mass index (LVW / BW) and heart rate index (HW / BW) of model group were significantly increased (P <0.01) (P <0.01) and left ventricular index (P <0.01), and decreased the levels of endothelin (P <0.01), interleukin 6 (P <0.01), angiotensin Ⅱ (P <0.01) and nitric oxide (P <0.01), and the Chinese medicine high dose group was superior to the traditional Chinese medicine low dose group (P <0.01). Ginseng Jianxin Capsule can reduce myocardial cell degeneration and inflammatory cell infiltration, with myocardial protection. Conclusion: Ginseng Jianxin Capsule can improve left ventricular hypertrophy in doxorubicin-induced heart failure rats, which may play a role in the regulation of neuroendocrine system and protect and repair myocardial damage caused by doxorubicin.