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目的分析通心络胶囊联合曲美他嗪在急性ST段抬高型心肌梗死(ASETMI)患者经皮冠状动脉介入(PCI)术后的应用效果。方法选取2014年9月—2016年6月在新疆医科大学附属中医医院心内科行PCI的ASETMI患者100例,按入院顺序分为对照组和观察组,每组50例。在PCI术后常规治疗基础上,对照组患者予以曲美他嗪治疗,而观察组患者予以通心络胶囊联合曲美他嗪治疗;两组患者均连续治疗12周。比较两组患者临床疗效、治疗前后心功能指标及6分钟步行距离。结果观察组患者临床疗效优于对照组(P<0.05)。治疗前两组患者左心室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)及左心室射血分数(LVEF)比较,差异无统计学意义(P>0.05);治疗后,观察组患者LVEDD、LVESD短于对照组,LVEF高于对照组(P<0.05)。治疗前两组患者6分钟步行距离比较,差异无统计学意义(P>0.05),而治疗后观察组患者6分钟步行距离长于对照组(P<0.05)。结论通心络胶囊联合曲美他嗪在ASETMI患者PCI术后的应用效果良好,可有效提高患者临床疗效,改善患者心功能。
Objective To analyze the effect of Tongxinluo capsule combined with trimetazidine in patients with acute ST-segment elevation myocardial infarction (ASETMI) after percutaneous coronary intervention (PCI). Methods From September 2014 to June 2016, 100 ASETMI patients undergoing PCI in the Department of Cardiology of the Affiliated Chinese Medicine Hospital of Xinjiang Medical University were divided into control group and observation group with 50 cases in each group. On the basis of routine treatment after PCI, patients in the control group were treated with trimetazidine, while patients in the observation group were treated with Tongxinluo capsule and trimetazidine. Both groups were treated continuously for 12 weeks. The clinical curative effect, heart function index and 6-minute walking distance before and after treatment were compared between the two groups. Results The clinical efficacy of the observation group was better than that of the control group (P <0.05). There was no significant difference in left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD) and left ventricular ejection fraction (LVEF) between the two groups before treatment (P> 0.05) LVEDD, LVESD shorter than the control group, LVEF higher than the control group (P <0.05). There was no significant difference in the 6-minute walk distance between the two groups before treatment (P> 0.05), while the 6-minute walking distance in the observation group was longer than that in the control group after treatment (P <0.05). Conclusion Tongxinluo capsule combined with trimetazidine in patients with ASETMI PCI after the effect is good, which can effectively improve the clinical efficacy of patients and improve cardiac function.