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背景:脑干听觉诱发电位(brainstemauditoryevokedpotentials,BAEP)和耳蜗电图(electrocochleogram,ECochG)两者综合波的新记录方法具有特殊临床意义,探讨体温升高和体温降低对其的影响对进一步明确E-CochG-BAEP综合波的生理特性和指导其临床应用有重要意义。目的:观察体温升高和体温降低对ECochG-BAEP综合波的影响效应。设计:随机区组设计。单位:暨南大学医学院生理教研室。对象:实验于2002-07/09在暨南大学医学院生理学教研室进行,选择成年豚鼠300～350g),雌雄不拘,由第一军医大学动物实验中心提供,(随机分为体温降低组(20只)和体温升高组(20只)。干预:体温降低组,体表物理降温法逐步降低豚鼠体温;体温升高组,体表物理升温法逐步升高豚鼠体温。主要观察指标:ECochG-BAEP综合波的波形、波峰潜伏期(PL)、波峰间潜伏期(IPL)和波幅随体温发生的变化。结果:随体温降低(36～25℃)和体温升高(36～42℃),E-CochG-BAEP综合波波形始终兼具BAEP和ECochG两者的特点,有十分明显突出的1波;各波PL和IPL随体温降低而逐步延长,但随体温升高而逐渐缩短;1,2,3波波幅在体温降低至30～29℃时开始出现显著降低,1,2波波幅也在体温升高至40℃后开始出现显著降低。结论:体温降低和体温升高对ECochG-BAEPSW的PL,IPL和波幅均有显著
BACKGROUND: The new method of recording the combined wave of brainstem acute auditory evoked potentials (BAEP) and electrocochleogram (ECochG) is of special clinical significance. To explore the effect of elevated body temperature and hypothermia on the new record method of E- The physiological characteristics of CochG-BAEP complex wave and its clinical application is of great significance. Objective: To observe the effects of body temperature increase and hypothermia on ECochG-BAEP complex wave. Design: Random block design. Unit: Department of Physiology, Jinan University Medical College. PARTICIPANTS: The experiment was conducted at the Department of Physiology, Jinan University Medical College from July to September 09, with 300 ~ 350g adult guinea pigs selected. Both sexes were randomly assigned to the Animal Experimental Center of First Military Medical University (randomly divided into hypothermia group (n = 20) And body temperature increase group (20) Intervention: body temperature decreased group, body surface physical cooling method to gradually reduce the body temperature of guinea pigs; body temperature increased group, physical warming body surface temperature gradually increased guinea pig body temperature.MAIN OUTCOME MEASURES: ECochG-BAEP synthesis Wave amplitude, peak latency (PL), latency between peaks (IPL) and amplitude with body temperature changes.Results: With the decrease of body temperature (36 ~ 25 ℃) and temperature rise (36 ~ 42 ℃), E-CochG- The BAEP integrated waveform always has the characteristics of both BAEP and ECochG, and has obvious one-wave. The PL and IPL of each wave gradually extend with the decrease of body temperature, but gradually shorten with the increase of body temperature. The amplitude of 1,2 wave began to decrease significantly when body temperature decreased to 30 ~ 29 ℃, and amplitude of 1,2 wave began to decrease after body temperature increased to 40 ℃ .Conclusion: The decrease of PL and IPL of ECochG-BAEPSW And volatility are significant