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目的总结江门市新会区新生儿败血症的临床特点,常见病原菌耐药情况。方法回顾分析2009年1月至2013年12月在新会区三间医院新生儿科确诊新生儿败血症的98例临床资料,对临床表现、病原菌及其耐药性进行比较分析。结论新生儿败血症表现均无特异性,早产儿多有呼吸暂停的临床表现。动态观察WBC和PLT的变化,若WBC和PLT进行性下降,多提示预后不良。CRP在感染后8~12小时迅速升高,是新生儿败血症的一个敏感指标。血培养检出致病菌仍以革兰氏阳性菌为主,占64.4%,CONS(35.5%)等条件致病菌仍是新生儿败血症的主要致病菌,对严重的革兰氏阳性球菌感染可首选万古霉素。碳青霉烯类对革兰氏阴性菌有较好的敏感性。
Objective To summarize the clinical features of neonatal sepsis in Xinhui District of Jiangmen City and the common pathogenic drug resistance. Methods The clinical data of 98 cases of neonatal sepsis diagnosed in neonatology from January 2009 to December 2013 in three hospitals of Xinhui District were retrospectively analyzed. The clinical manifestations, pathogenic bacteria and their drug resistance were compared. Conclusions The performance of neonatal sepsis is nonspecific. There are more clinical manifestations of apnea in preterm infants. Dynamic observation of changes in WBC and PLT, WBC and PLT progressive decline, suggesting that poor prognosis. CRP in 8 to 12 hours after infection rapidly increased, is a sensitive indicator of neonatal sepsis. Gram-positive bacteria were still the main pathogenic bacteria detected in blood culture, accounting for 64.4%. CONS (35.5%) and other pathogenic bacteria were still the main pathogenic bacteria of neonatal sepsis. Gram-positive cocci Infection may be the preferred vancomycin. Carbapenems have good sensitivity to Gram-negative bacteria.