食管胃底曲张静脉破裂出血是肝硬化的危重并发症,其首次出血死亡率高达50％。因此这类病人出血即期处理尤为重要。我院1995～1998年应用善得定治疗食管胃底曲张静脉破裂大出血20例(22次)及同期应用垂体后叶素治疗食管胃底曲张静脉破裂大出血22例(23次)进行疗效分析,报告如下。 1.资料和方法 对象 (1)所有病例均有呕血和或黑粪,暗红色血便等急性上消化道出血表现,经胃镜和/或食管吞钡X线摄片证实为食管胃底曲张为观察组病例,合并严重心肺肾脑疾患及孕妇除外。出血量均在1000ml以上,伴有头昏或昏厥,出冷汗,血压偏低,心率快等低血容量症状;(2)肝硬化病史1～25年,肝功能Child—Pugh改良分级法以血清胆红素、腹水、血清白蛋白浓度,肝 Esophageal variceal bleeding is a critical complication of cirrhosis, with a mortality rate of up to 50% for the first time. Therefore, the spot treatment of such patients is particularly important. Our hospital from 1995 to 1998, good use of fixed treatment of esophageal and gastric variceal bleeding in 20 cases (22 times) and pituitrin at the same period treatment of esophageal variceal bleeding in 22 cases (23 times) for the efficacy analysis, report as follows. 1. Materials and Methods Subjects (1) all cases of hematemesis and or black manure, dark red bloody stool and other acute upper gastrointestinal bleeding, endoscopy and / or esophageal barium X-ray confirmed esophageal varices as observed Group of patients with severe cardiopulmonary and renal disorders and pregnant women excluded. Bleeding more than 1000ml, accompanied by dizziness or fainting, cold sweats, low blood pressure, heart rate and other hypovolemia symptoms; (2) a history of cirrhosis 1 to 25 years, liver function Child-Pugh improved grading method to serum Bilirubin, ascites, serum albumin, liver