论文部分内容阅读
纳洛酮1960年合成,1963年开始用于临床,作为阿片受体的特异性拮抗剂,已广泛应用于阿片类药物过量引起的呼吸抑制,急性乙醇中毒等的解救。近年来随着研究深入,老药也有了新的用途。纳洛酮(烯丙羟吗啡酮)是阿片类受体拮抗药,可与阿片受体呈立体专一性结合,阻止吗啡样物质与受体结合。临床主要用于阿片类药物复合麻醉术后,拮抗该类药物所致的呼吸抑制,促使患者苏醒,阿片类药物过量引起的呼吸抑制,急性乙醇中毒,以及急性阿片类药物过量的诊断。近年来随着医药科学的发展和临床使用的深入,其应用范围逐渐扩大。
Naloxone was synthesized in 1960 and began to be used clinically in 1963. As a specific antagonist of opioid receptors, naloxone has been widely used in the rescuing of respiratory depression and acute ethanol poisoning caused by opioid overdose. In recent years, with the deepening of research, the old drugs also have new uses. Naloxone (alcoxymetrone) is an opioid receptor antagonist that binds stereospecifically to opioid receptors and blocks the binding of morphine-like substances to receptors. Clinic is mainly used for opioid compound anesthesia, antagonize the respiratory depression caused by these drugs, to promote the patient awake, opioid respiratory depression caused by excessive, acute alcoholism, and acute opioid overdose diagnosis. In recent years, with the development of medical science and clinical use, the scope of its application has been gradually expanded.