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目的 :观察伊马替尼联合VCP低剂量诱导治疗8例成人Ph阳性急性淋巴细胞白血病高白细胞血症的疗效。方法 :8例患者均应用伊马替尼联合VCP低剂量诱导方法治疗,观察其临床疗效。结果 :8例患者,经过治疗后白细胞计数均恢复正常,血红蛋白及血小板均有不同程度的升高。6例患者获得完全缓解,2例患者为部分缓解。结论 :伊马替尼联合VCP低剂量诱导治疗成人Ph阳性急性淋巴细胞白血病高白细胞血症安全性高,可获得满意的CR率,延长患者的生存期。
Objective: To observe the curative effect of imatinib combined with low-dose VCP in the treatment of 8 cases of adult Ph-positive acute lymphoblastic leukemia hyper leucocytosis. Methods: All 8 patients were treated with low dose of imatinib combined with VCP and the clinical efficacy was observed. Results: In 8 patients, white blood cell count returned to normal after treatment, hemoglobin and platelets were increased to varying degrees. 6 patients achieved complete remission, 2 patients were partially relieved. Conclusion: Imatinib combined with low-dose VCP induction therapy is safe and effective in the treatment of adult Ph-positive acute lymphoblastic leukemia with high serum leucocythemia, and satisfactory CR rate can be obtained to prolong the survival of patients.