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自从Crüntzig成功地在人体进行经皮腔内冠状动脉成形术(PTCA)以来,由于导管、导丝系统的不断改进和手术经验的增加,各种急性并发症和死亡率均明显下降,适应证不断拓宽。但十几年来PTCA后冠状动脉(简称冠脉)再狭窄率却无明显改善。本文拟对其机理及其防治的研究进展作一简要介绍。一、再狭窄的定义及促成再狭窄的因素目前对PTCA后再狭窄尚无一致定义,因而报道的发生率不一。美国科学院心肺血液研究院(NHLBI)对再狭窄定义为成功的PTCA后至随访冠脉造影时,病人冠脉原扩张部位狭窄程度至少增加30％,或已经成形管腔扩大部分在随访时至少减少50％。根据NHLBI等对1544例成功的PTCA
Since Crüntzig’s successful percutaneous transluminal coronary angioplasty (PTCA) in humans, various acute complications and mortality have dropped significantly due to the continuous improvement of the catheter and guide wire system and surgical experience Broaden. However, after more than a decade PTCA coronary artery (referred to as coronary) restenosis rate but no significant improvement. This article intends to make a brief introduction of the research progress of its mechanism and its prevention and cure. First, the definition of restenosis and the factors that contribute to restenosis There is no consistent definition of post-PTCA restenosis, and thus the reported incidence varies. American Academy of Sciences Cardiorespiratory Institute (NHLBI) Restenosis, defined as successful PTCA followed by coronary angiography, at least 30% increase in stenosis at the site of coronary prolapse or at least a reduction in the length of the enlarged lumen at follow-up 50%. According to NHLBI and other 1544 cases of successful PTCA