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作者对9例14～72岁原发性血小板增多症患者用α-2b 干扰素治疗。全部患者以往无任何特殊治疗。2例因脾静脉血栓形成做过脾切除,其中1例又因肠系膜静脉血栓形成而做过小肠部分切除;另1例则并发门静脉梗阻和食管静脉曲张;1例发生过中风;1例有严重雷诺氏现象;4例均无与基础病相关症状。最初血小板计数900～2430(中数1650)×10(?)/L。全部患者诱导治疗每天用皮下注射α-2b 干扰素4×10(?)U/M~2。3～12(中数4)个月血小板全部降至正常。此后予以2～6×10(?)(中数3.5)U/d 足以维持血小板计数正常。1～26(中数15)个月随访,恶性血小板增多症除1例外均得到持续有效控制。此例患者在α-干扰素治疗15个月后,再合用α-2b 干扰素(5×10(?)U/d)和γ-干扰素(50U/d),血小板
The authors treated 9 patients 14 to 72 years of age with essential thrombocythemia in patients treated with interferon alfa-2b. All patients in the past without any special treatment. Two patients underwent splenectomy due to splenic vein thrombosis, one of which underwent partial resection of the small intestine due to mesenteric venous thrombosis, the other one had portal vein obstruction and esophageal varices, one had a stroke and one had severe Raynaud’s phenomenon; 4 cases were not associated with underlying disease-related symptoms. The initial platelet count 900 ~ 2430 (median 1650) × 10 (?) / L. All patients were induced by daily subcutaneous injection of α-2b interferon 4 × 10 (?) U / M ~ 2.3 ~ 12 (median 4) months, all platelets returned to normal. Since then to 2 ~ 6 × 10 (?) (3.5) U / d sufficient to maintain normal platelet count. 1 ~ 26 (median 15) months follow-up, except for one case of malignant thrombocytosis were sustained and effective control. After 15 months of alpha interferon treatment, patients in this group were then treated with interferon alfa-2b (5 x 10 (?) U / d) and interferon gamma (50 U / d)