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[目的]评价成人按“0-1-3月”“0-1-6月”和“0-1-12月”免疫程序接种乙型肝炎(乙肝)疫苗的免疫效果和持久性,为制定成人免疫策略提供依据。[方法]选择浙江省桐乡市16~49岁人群,按照自愿原则,分3种免疫程序接种10μg乙肝疫苗,全程免疫1个月和1年后定量检测抗-HBs,评价不同免疫程序接种后的抗-HBs阳转率、抗体浓度水平。[结果]共682人完成全程免疫并采集双份免疫后血样。全程免疫1个月后抗-HBs阳转率为99.85%,免疫1年后阳转率为70.23%,免疫年龄越低,抗-HBs阳转率和抗-HBs几何平均滴度越高。[结论]成年人接种10μg乙肝疫苗可获得较好的免疫效果,按“0-1-6月”免疫程序接种,目标人群依从性更好,免疫效果更持久。建议成年人尽早接种乙肝疫苗,以保证疫苗的免疫效果和持久性。
[Objective] To evaluate the immunologic effect of hepatitis B vaccine inoculated by “0-1-3 month”, “-0-1-6 month” and “-0-1-12 month” immunization programs in adults. And persistence, to provide a basis for the development of adult immunization strategies. [Methods] The population of 16-49 years old in Tongxiang City of Zhejiang Province was selected. According to the voluntary principle, 10 μg of hepatitis B vaccine was inoculated into 3 kinds of immunization programs. Anti-HBs were quantitatively detected after 1 and 1 year of whole immunization. Anti-HBs positive conversion rate, antibody concentration level. [Results] A total of 682 people completed the whole immunization and collected double immunized blood samples. After one month of full immunization, the positive rate of anti-HBs was 99.85%, and the positive rate of one year after immunization was 70.23%. The lower the immunization age, the higher the geometric mean titer of anti-HBs positive rate and anti-HBs. [Conclusion] Adults vaccinated with 10μg Hepatitis B vaccine can get better immune effect. According to the “0-1-6 month” vaccination program, the target population has better compliance and the immune effect is more durable. It is recommended that adults vaccinate hepatitis B vaccine as soon as possible to ensure the vaccine’s immune effect and persistence.