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有研究文献观察到急性运动后认知功能提高,但支持该作用的生物机制仍然证据有限。对啮齿类动物及人类的研究发现,脑源性神经营养因子(BDNF)可能是该作用的潜在机制。BDNF的分子属性使其能进行外围检测(p BDNF)(如血清和血浆),促使急性运动诱导的BDNF浓度变化相对可测。对“急性运动—BDNF—认知功能”关系的现有研究结果各异,但其原因主要是各研究采用不同方法,而不在于BDNF的作用。例如,记忆力评估研究发现有急性运动诱发的BDNF浓度变化和认知功能显著相关,但两者的联系在评估非记忆力认知领域的研究中并不显著。针对未来理解这一关系中BDNF作为生物机制的研究提出3点建议:1.关注不同类型的记忆(如关联记忆、空间记忆、长期记忆等)有利于评估认知功能;2.可以用更精细的p BDNF测量来检测BDNF蛋白特定的异构体(如成熟和未成熟的);3.可应用统计学技术来检测p BDNF在“急性运动—认知功能”关系中的调节作用,以此做出因果推论。
Some studies have observed that cognitive function is improved after acute exercise, but the biological mechanisms that support this role remain limited. Studies in rodents and humans have found that brain-derived neurotrophic factor (BDNF) may be a potential mechanism for this effect. The molecular nature of BDNF makes it possible to peripherally detect (p BDNF), such as serum and plasma, and make the change in BDNF concentrations that are induced by acute exercise relatively measurable. Existing research findings on the relationship of “acute motor-BDNF-cognitive function” vary, but the main reason is that different approaches are used in each study, not the role of BDNF. For example, memory assessment studies found that acute exercise-induced changes in BDNF concentrations correlate significantly with cognitive function, but the association between the two is not significant in assessing non-memory cognitive domains. For the future to understand the relationship between BDNF as a biological mechanism of the study made three suggestions: 1. Pay attention to different types of memory (such as associated memory, spatial memory, long-term memory, etc.) is conducive to assessing cognitive function; (Eg, mature and immature) of BDNF protein using the p BDNF measurement; 3. Modulation of p BDNF in “acute motor-cognitive function” relationships can be tested using statistical techniques, To make causal inferences.