目的合成头孢唑兰中间体(Z)-2-(5-氨基-1,2,4-噻二唑-3-基)-2-甲氧亚氨基乙酸。方法以氰乙酰胺为起始原料,依次经甲氧亚氨化、加成、酯化、与硫氰化钾反应、构型转换和水解共6步反应制得目标化合物。结果与结论目标化合物的结构经1H-NMR和MS谱确证。该工艺路线原料易得,操作简便,总收率为29.8%,具有一定的工业化价值。 Objective To synthesize cefazolin intermediate (Z) -2- (5-amino-1,2,4-thiadiazol-3-yl) -2-methoxyiminoacetic acid. Methods Cyanoacetamide as the starting material, followed by methoxyimination, addition, esterification, and potassium thiocyanate reaction, configuration conversion and hydrolysis of a total of six-step reaction of the target compound. Results and Conclusions The structures of target compounds were confirmed by 1H-NMR and MS spectra. The process of raw materials easily available, easy to operate, the total yield of 29.8%, with a certain degree of industrial value.