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目的探讨规律有氧运动对2型糖尿病患者的内皮功能的影响。方法 110例2型糖尿病患者分为运动试验组(n=58)和对照组(n=52),对照组给予单纯糖尿病常规治疗,运动试验组为糖尿病常规治疗的基础上,选择规律有氧运动锻炼(快步走、慢跑、太极拳及游泳等),比较经过6个月有氧运动锻炼后的试验组患者和对照组患者肱动脉内皮依赖性扩张(FMD)和非内皮依赖性舒张功能(NMD)的差异以及运动试验组与对照组患者自身6个月前后各指标的变化。结果经过6个月的规律有氧运动后,运动试验组患者的空腹血糖、HbA1c、体重、BMI、腰臀比和甘油三酯(TG)较有氧运动前下降(P<0.05),肱动脉FMD提高[(6.45±2.83)%vs.(5.20±2.61)%,P=0.019],肱动脉NMD没有变化[(13.78±7.30)%vs.(12.99±6.32)%,P=0.413];与对照组比较,运动试验组患者空腹血糖、HbA1c、体重、BMI和TG低于对照组(P<0.05),肱动脉FMD高于对照组[(6.45±2.83)%vs.(5.37±2.29)%,P=0.033],NMD在两组间没有统计学差异[(13.78±7.30)%vs.(12.67±7.09)%,P=0.245];未进行有氧运动锻炼的对照组在6个月前后FMD和NMD没有明显变化(P>0.05)。结论有氧运动能帮助2型糖尿病患者降低血糖水平,控制体重,对提高内皮功能有积极的影响。
Objective To investigate the effect of regular aerobic exercise on endothelial function in type 2 diabetic patients. Methods One hundred and ten patients with type 2 diabetes were divided into exercise test group (n = 58) and control group (n = 52). The control group was treated with routine diabetes mellitus. The exercise test group was given routine aerobic exercise Exercise (walking, jogging, tai chi and swimming, etc.) compared bradyndocardial endothelium-dependent dilatation (FMD) and non-endothelium-dependent diastolic function in the test group and control group after 6 months of aerobic exercise NMD), and the changes of each index of patients in exercise test group and control group six months ago. Results After 6 months’ regular aerobic exercise, the fasting blood glucose, HbA1c, body weight, BMI, waist-hip ratio and triglyceride in exercise test group decreased significantly compared with before aerobic exercise (P <0.05) There was no change in NMD of brachial artery in FMD group [(6.45 ± 2.83)% vs (5.20 ± 2.61)%, P = 0.019], but not in brachial artery (13.78 ± 7.30% vs 12.99 ± 6.32%, P = 0.413) Compared with the control group, the fasting blood glucose, HbA1c, body weight, BMI and TG in the exercise test group were significantly lower than those in the control group (P <0.05). The FMD in the brachial artery was higher than that in the control group [(6.45 ± 2.83)% vs (5.37 ± 2.29)% , P = 0.033]. There was no significant difference in NMD between the two groups [(13.78 ± 7.30)% vs (12.67 ± 7.09)%, P = 0.245]. In the control group without aerobic exercise, FMD and NMD did not change significantly (P> 0.05). Conclusion Aerobic exercise can help reduce the blood sugar level, control the body weight of patients with type 2 diabetes and has a positive effect on the improvement of endothelial function.