论文部分内容阅读
以氯丙酮和三苯基膦为原料反应制得磷叶立德,在无溶剂的微波条件下,磷叶立德与3-吡啶甲醛经Wittig反应制得4-(3-吡啶基)-3-丁烯-2-酮。反应后用二氯甲烷萃取,无水硫酸钠干燥,除去溶剂后得到纯净产物。反应时间为1min,产率达100%。
Chloropropanone and triphenylphosphine were used as raw materials to prepare phosphonium ylide. Wittig reaction of phosphorus ylide with 3-pyridinecarboxaldehyde in a solvent-free microwave environment gave 4- (3-pyridyl) -3-butene- 2-one. After the reaction was extracted with dichloromethane, dried over anhydrous sodium sulfate, the solvent was removed to give the pure product. The reaction time was 1min, the yield reached 100%.